PNA bearing 5-azidomethyluracil A novel approach for solid and solution phase modification
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چکیده
Abbreviations: AcOEt, ethyl acetate; Boc, t-butoxycarbonyl; DCC, N,N'-dicyclohexylcarbodiimide; DCM, dichloromethane; DhBtOH, 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; DIC, N,N'-diisopropylcarbodiimide; DIPEA, diisopropylethylamine; DMF, N,N-dimethylformamide; DMSO, dimethylsulfocide; EDC, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; FA, formic acid; Fmoc, 9-fluorenylmethoxycarbonyl; MeOH, methanol; TFA, trifluoroacetic acid; TFMSA, trifluoromethanesulfonic acid; THF, tetrahydrofuran; XIC, extracted ion current
منابع مشابه
PNA bearing 5-azidomethyluracil
Fmoc- and Boc-protected modified monomers bearing 5-azidomethyluracil nucleobase were synthesized. Four different solid-phase synthetic strategies were tested in order to evaluate the application of this series of monomers for the solid-phase synthesis of modified PNA. The azide was used as masked amine for the introduction of amide-linked functional groups, allowing the production of a library...
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تاریخ انتشار 2012